Interim Department Chair; Professor, Brain & Cognitive Sciences
Dr. Michael Hoane received his Ph.D. in Behavioral Neuroscience from Texas Christian University in 1996. His post-doctoral training in neuroscience was conducted at Emory University School of Medicine, CytoTherapeutics, and the Northwestern University School of Medicine. The mission of his Restorative Neuroscience Laboratory is to use state of the art preclinical technologies to develop treatments for traumatic brain injuries (TBI). Within the framework of developing these treatments he also is investigating the pathophysiological and neural plastic changes that occur in the brain following injury, especially those associated with age. Currently, a variety of animal models are used in his laboratory to accomplish these goals and to investigate the ability of novel therapies to facilitate recovery of function on a wide range of behavioral and histological assays. One of his current, and most active, lines of research includes the examination of the preclinical efficacy of various vita-nutrient therapies (e.g., B-vitamins) and other novel compounds following traumatic brain injury. Another major research interest is the continued development and refinement of our preclinical animal models of TBI to increase their potential translatability to the human TBI condition, which includes the examination of frontal lobe mediated behaviors and cognition. In addition, his laboratory is beginning to examine the role of rehabilitative strategies and aging following TBI.
Ph.D., Texas Christian University
effects of vita-nutrients in brain injury and neurodegenerative diseases
PSYC 302: Intro to Neuroscience
PSYC 415: Psychopharmacology
PSYC 514: Neurobiological Bases of Behavior
PSYC 518: Psychopharmacology and Behavior
Vonder Haar, C., Peterson, T.C., Martens, K.M., & Hoane, M.R. (2013). The use of nicotinimide as a treatment for experimental traumatic brain injury and stroke: A review and evaluation. Clinical Pharmacology & Biopharmaceutics, in press.
Martens, K.M., Vonder Haar, C., Hutsell, B.A., & Hoane, M.R. (2013). The dig task: A simple scent discrimination reveals deficits following frontal brain damage. Journal of Visualized Experiments, 71, 1-6. http://www.jove.com/video/50033
Anderson, G.D., Peterson, T.C., Farin, F.M., Bammler, T.K., Beyer, R.P., Kantor, E.D., & Hoane, M.R. (2013). The effect of nicotinimide on gene expression in a traumatic brain injury model. Frontiers in Neuroscience, in press.
Martens, K.M., Vonder Haar, C., Hutsell, B., & Hoane, M.R. (2012). A simple discrimination task used as a novel method of testing decision-making behavior following traumatic brain injury in the rat. Journal of Neurotrauma, 29, 2505-2512.
Peterson, T.C., Kantor, E.D., Anderson, G.D., & Hoane, M.R. (2012). A comparison of the effects of nicotinimide and progesterone on functional recovery of cognitive behavior following cortical contusion injury in the rat. Journal of Neurotrauma, 29, 2823-2830.
Quigley, A., Tan, A.A., & Hoane, M.R. (in press). The effects of hypertonic saline and nicotinamide on behavioral and cognitive function following cortical contusion injury in the rat. Brain Research.
Hoane, M.R., Kaufman, N.A., Vitek, M.P., & McKenna, S.E. (2009). COG1410 improves cognitive performance and reduces cortical neuronal loss in the traumatically injured brain. Journal of Neurotrauma, 26, 121-130.
Young, M.E., Clark, M.H., Goffus, A., & Hoane, M.R. (2009). Mixed effects modeling of Morris water maze data: Advantages and cautionary notes. Learning and Motivation, 40, 160-177.
Tan, A.A., Quigley, A., Smith, D.C., & Hoane, M.R. (2009). Strain differences in response to traumatic brain injury in Long Evans compared to Sprague-Dawley rats. Journal of Neurotrauma, 26, 539-548.
Hoane, M.R., Gilbert, D.R., Barbre, A.B., & Harrison, S.A. (2008). Magnesium dietary manipulation and recovery of function following controlled cortical damage in the rat. Magnesium Research, 21, 29-37.
Kolowski, D.A., & Hoane, M.R. Neuroprotection and neuroplasticity following traumatic brain injury. Brain Injury Association of America’s, Essential Brain Injury Guide, in press.
Hoane, M.R. (2011). The role of magnesium therapy in learning and memory. In R. Vink and M. Nechifor (Eds.), Magnesium in the Central Nervous System, (pp. 115-124) University of Adelaide Press; Aldelaide, AU.
Hoane, M.R. (2012). The role of magnesium in the pathophysiology and treatment of stroke and other neurological injuries. In Y. Li and J. Zhang (Eds.), Stroke Metals, (pp. 431-444) Springer; New York.